Kügler J, Zantow J, Meyer T et al (2013) Oligopeptide m13 phage display in pathogen research. Prostaglandins Leukot Essent Fatty Acids 45(4):319–327 Kort WJ, Bijma AM, van Dam JJ et al (1992) Eicosanoids in breast cancer patients before and after mastectomy. Jatoi I, Anderson WF, Jeong JH et al (2011) Breast cancer adjuvant therapy: Time to consider its time-dependent effects. Hammamieh R, Sumaida D, Zhang X et al (2007) Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism. Halin C, Gafner V, Villani ME et al (2003) Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha. Gray BP, Brown KC (2014) Combinatorial peptide libraries: mining for cell-binding peptides. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Goldhirsch A, Wood WC, Coates AS et al (2011) Strategies for subtypes–dealing with the diversity of breast cancer: highlights of the St. Molecules 6(2):1776–1803įagerlund A, Myrset AH, Kulseth MA (2014) Construction of a filamentous phage display peptide library. Eur J Nucl Med Mol Imaging 30(3):463–469ĭerda R, Tang SK, Li SC et al (2011) Diversity of phage-displayed libraries of peptides during panning and amplification. Curr Pharm Des 24(11):1195–1203ĭe Jong M, Kwekkeboom D, Valkema R et al (2003) Radiolabelled peptides for tumour therapy: current status and future directions. Īrab A, Robati RY, Nicastro J et al (2018) Phage-based nanomedicines as new immune therapeutic agents for breast cancer. The peptide, CSB1 is of the potential as a candidate to be used for developing the new approaches of molecular imaging detection and targeting chemotherapy of breast cancer in the future.Īnderson WF, Rosenberg PS, Katki HA (2014) Tracking and evaluating molecular tumor markers with cancer registry data: HER2 and breast cancer. Bioinformatics analysis suggested that the peptide CSB1 targets the 5-Lipoxygenase-Activating Protein (FLAP), which has been implicated in breast cancer progression and prognosis. The consequently results under immunofluorescence and laser scanning confocal microscope (LSCM) indicated that CSB1 bound MCF-7 cells and breast cancer tissues specifically and sensitively with high affinity. Resultsīy a phage-displayed peptide library, a 12-mer peptide, CSB1 was screened out using MCF-7 cells as the target. Development of the new approaches for breast cancer targeted diagnosis and chemotherapy is emergently needed by the current clinical practice, the important first step is finding a breast cancer specifically binding molecule or fragment as early clinical indicators.
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Breast cancer is a popular fatal malignant tumor for women with high of rates incidence and mortality.